Ningbo Chin-Mo Import & Export Co., Ltd.

L-Serine

L-Serine
Product Detailed

L-Serine
Molecule Formula: C3H7NO3
Molecule Weight: 105.09
Manufacture Standards: AJI92,USP26,EP4

L-Serine

Indications and Usage
Serine (abbreviated as Ser or S) is an organic compound with the formula HO2CCH(NH2)CH2OH.It is one of the naturally occurring proteinogenic amino acids. Its codons are UCU, UCC, UCA, UCG, AGU and AGC. Only the L-stereoisomer appears naturally in proteins. It is not essential to the human diet, since it is synthesized in the body from other metabolites, including glycine. Serine was first obtained from silk protein, a particularly rich source, in 1865. Its name is derived from the Latin for silk, sericum. Serine's structure was established in 1902. By virtue of the hydroxyl group, serine is classified as a polar amino acid.

 

The biosynthesis of serine starts with the oxidation of 3-phosphoglycerate to 3-phosphohydroxypyruvate and NADH. Reductive amination of this ketone followed by hydrolysis gives serine. Serine hydroxymethyltransferase catalyzes the reversible, simultaneous conversions of L-serine to glycine (retro-aldol cleavage) and 5,6,7,8-tetrahydrofolate to 5,10-methylenetetrahydrofolate (hydrolysis).

 

Serine plays an important role in the catalytic function of many enzymes. It has been shown to occur in the active sites of chymotrypsin, trypsin, and many other enzymes. The so-called nerve gases and many substances used in insecticides have been shown to act by combining with a residue of serine in the active site of acetylcholine esterase, inhibiting the enzyme completely. The enzyme acetylcholineesterase breaks down the neurotransmitter acetylcholine, which is released at nerve and muscle junctions in order to allow the muscle or organ to relax. The result of acetylcholine inhibition is that acetylcholine builds up and continues to act so that any nerve impulses are continually transmitted and muscle contractions do not stop.


As a constituent (residue) of proteins, its side chain can undergo O-linked glycosylation, which may be functionally related to diabetes. It is one of three amino acid residues that are commonly phosphorylated by kinases during cell signaling in eukaryotes. Phosphorylated serine residues are often referred to as phosphoserine. Serine proteases are a common type of protease.


Package
25kg/drum, double layers plastic bags inside.

 

Storage Situation
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.



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